9/17/2023 0 Comments Supplements for migraine with aura![]() ![]() Magnesium in the prophylaxis of migraine-a double-blind placebo-controlled study. Pfaffenrath V, Wessely P, Meyer C, et al. ![]() Prophylaxis of migraine with oral magnesium: results from a prospective, multi-center, placebo-controlled and double-blind randomized study. Magnesium prophylaxis of menstrual migraine: effects on intracellular magnesium. 2009 80(2):157-162.įacchinetti F, Sances G, Borella P, Genazzani AR, Nappi G. Role of magnesium in the pathogenesis and treatment of migraines. Role of magnesium, coenzyme Q10, riboflavin, and vitamin B12 in migraine prophylaxis. 2009 9(3):369-379.īianchi A, Salomone S, Caraci F, Pizza V, Bernardini R, D’Amato CC. ![]() Role of magnesium in the pathogenesis and treatment of migraine. Magnesium citrate seems to be the preferred oral magnesium supplement for migraine prevention however, further studies comparing the efficacy of different oral magnesium supplements are needed. Magnesium chloride had never introduced as migraine prophylactic agent in clinical trials. No different in migraine frequency or severity between Mg-oxide and placebo in RCT conducted in children while Only Mg-oxide containing groups showed significant reduction in migraine days when compared to control (p<0.006) in RCT conducted in adults. Magnesium oxide was used in combination with magnesium citrate in 2 randomized clinical trials (RCTs), and used alone in one RCT in adults and children. Migraine attack frequency and intensity were significantly lower in magnesium citrate group compared to placebo with 41.6-64% and 43-59% reduction in migraine attack frequency and severity frequently. Magnesium citrate was used as single oral migraine prophylactic supplement in most of the published trials. Keywords included migraine, prophylaxis, and magnesium. A literature review using MEDLINE, Scopus, Cochrane library, and EMBASE was conducted during the period from Novemuntil December 30, 2015. The objective was to identify the efficacy of different oral magnesium supplements in migraine prophylaxis. Different magnesium supplements have different oral absorption and bioavailability. No study was conducted to evaluate the efficacy of particular oral magnesium supplement over another in preventing migraine. ![]()
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